Domoic Acid

• CAT Number: R056495
• CAS Number: 14277-97-5
• Molecular Formula: C15H21NO6
• Molecular Weight: 311.33
• Purity: 98%
• Synonyms: (2S,3S,4S)-2-Carboxy-4-[(1Z,3E,5R)-5-carboxy-1-methyl-1,3-hexadien-1-yl]-3-pyrrolidineacetic Acid; (-)-Domoic Acid; L-Domoic Acid; NSC 288031;
• Target: Kainate Receptors
• Solubility: Soluble to 50 mM in sterile water
• Storage: Desiccate at -20°C
• IUPAC Name: (2S,3S,4S)-4-[(2Z,4E,6R)-6-carboxyhepta-2,4-dien-2-yl]-3-(carboxymethyl)pyrrolidine-2-carboxylic acid
• InChI: InChI=1S/C15H21NO6/c1-8(4-3-5-9(2)14(19)20)11-7-16-13(15(21)22)10(11)6-12(17)18/h3-5,9-11,13,16H,6-7H2,1-2H3,(H,17,18)(H,19,20)(H,21,22)/b5-3+,8-4-/t9-,10+,11-,13+/m1/s1
• InChIKey: VZFRNCSOCOPNDB-AOKDLOFSSA-N
• SMILES: CC(C=CC=C(C)C1CNC(C1CC(=O)O)C(=O)O)C(=O)O

Domoic Acid(Cat No.: R056495) is a naturally occurring toxin produced by certain species of marine microalgae, such as Pseudo-nitzschia spp., and causes Amnesic Shellfish Poisoning (ASP) in humans and wildlife when consumed via contaminated shellfish or other seafood. Domoic acid is a potent neurotoxin that can cause damage to the brain and nervous system, leading to symptoms such as vomiting, diarrhea, confusion, seizures, and in severe cases, coma or death.

Reference

1. Hampson, David R., and Jerrie Lynn Manalo. "The activation of glutamate receptors by kainic acid and domoic acid." Natural toxins 6.3‐4 (1998): 153-158.
2.Hampson, David R., et al. "Interaction of domoic acid and several derivatives with kainic acid and AMPA binding sites in rat brain." European journal of pharmacology 218.1 (1992): 1-8.