For research use only. Not for therapeutic Use.
Dooku1, an analog of Yoda1, is a selective antagonist of the endogenous Piezo1 channel. Dooku1 inhibited 2 μM Yoda1-induced Ca2+-entry with IC50 values of 1.3 μM (in HEK 293 cells) and 1.5 μM (in HUVECs). Dooku1 inhibits Yoda1-induced relaxation of aorta[1].
| Catalog Number | I018098 |
| CAS Number | 2253744-54-4 |
| Molecular Formula | C₁₃H₉Cl₂N₃OS |
| Purity | ≥95% |
| Target | Piezo Channel |
| Reference | [1]. Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175(10):1744-1759. |
