Dopamine D2 receptor antagonist-1

• CAT Number: I017558
• CAS Number: 1055411-77-2
• Molecular Formula: C14H17N3S
• Molecular Weight: 259.37
• Purity: ≥95%
• Synonyms: N-cyclobutyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amine
• InChI: InChI=1S/C14H17N3S/c1-2-7-11-10(6-1)12-13(17-9-4-3-5-9)15-8-16-14(12)18-11/h8-9H,1-7H2,(H,15,16,17)
• InChIKey: ANUJDLRACOBTTB-UHFFFAOYSA-N
• SMILES: C1CCC2=C(C1)C3=C(N=CN=C3S2)NC4CCC4

Dopamine D2 receptor antagonist-1 is a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R) with sub-mM affinity[1].

Reference

[1]. Fyfe TJ, et al. Subtle modifications to a thieno[2,3-d]pyrimidine scaffold yield negative allosteric modulators and agonists of the dopamine D2 receptor. Eur J Med Chem. 2019 Apr 15;168:474-490.
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