For research use only. Not for therapeutic Use.
Doripenem（Cat No.:I001815）is a broad-spectrum carbapenem antibiotic effective against a wide range of gram-positive and gram-negative bacteria, including difficult-to-treat pathogens such as Pseudomonas aeruginosa. It works by inhibiting bacterial cell wall synthesis, leading to cell death. Doripenem is particularly valuable for treating severe infections like complicated urinary tract infections, intra-abdominal infections, and hospital-acquired pneumonia. Known for its stability against most beta-lactamases, it is a reliable option in cases of multidrug-resistant infections. Administered intravenously, Doripenem is widely used in hospital settings for critically ill patients.
| Catalog Number | I001815 |
| CAS Number | 148016-81-3 |
| Synonyms | (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-[(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid |
| Molecular Formula | C15H24N4O6S2 |
| Purity | ≥95% |
| Target | Antibiotic |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20C |
| IUPAC Name | (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-[(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid |
| InChI | InChI=1S/C15H24N4O6S2/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26-9-3-8(17-5-9)4-18-27(16,24)25/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,23)(H2,16,24,25)/t6-,7-,8+,9+,10-,11-/m1/s1 |
| InChIKey | AVAACINZEOAHHE-VFZPANTDSA-N |
| SMILES | C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]3C[C@H](NC3)CNS(=O)(=O)N)C(=O)O)[C@@H](C)O |
| Reference | <p style=/line-height:25px/> <br>[2]. Jones RN, et al. Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations. J Antimicrob Chemother. 2004 Jul;54(1):144-54. Epub 2004 Jun 9. </p> |
