Dorsmorphin dihydrochloride

• CAT Number: I000838
• CAS Number: 1219168-18-9
• Molecular Formula: C₂₄H₂₅N₅O.2HCl
• Molecular Weight: 472.41
• Purity: ≥95%
• Synonyms: 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine;dihydrochloride
• Target: AMPK
• Solubility: DMSO: ≤ 5.2 mg/mL (Need ultrasonic)
• Storage: Store at -20 C
• IC50: 109 nM (Ki for AMPK)
• InChI: InChI=1S/C24H25N5O.2ClH/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20;;/h4-11,16-18H,1-3,12-15H2;2*1H
• InChIKey: RJDVIJJQKMGPMV-UHFFFAOYSA-N
• SMILES: C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl

Dorsomorphin dihydrochloride（Cat No.:I000838）is a potent and selective inhibitor of AMP-activated protein kinase (AMPK), a critical regulator of cellular energy balance. This compound is utilized in research to explore the effects of AMPK inhibition on metabolic processes, including glucose and lipid metabolism. Dorsomorphin dihydrochloride has shown promise in studies related to obesity, diabetes, and cancer, where altered AMPK activity plays a significant role. Its unique mechanism allows researchers to investigate the complex regulatory pathways governing energy homeostasis and metabolic adaptation, contributing to a better understanding of metabolic diseases.

Reference

[1]. Jin J, et al. AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. J Lipid Res. 2009 Dec;50(12):2389-97.
[2]. Saito S, et al. Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling. PLoS One. 2012;7(9):e45845.
[3]. Vucicevic L, et al. Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. Autophagy. 2011 Jan;7(1):40-50.