For research use only. Not for therapeutic Use.
Dorsomorphin dihydrochloride（Cat No.:I013941）is a selective inhibitor of AMP-activated protein kinase (AMPK), primarily known for its role in regulating cellular energy homeostasis. This compound disrupts metabolic pathways, providing insights into the mechanisms underlying metabolic diseases, obesity, and cancer. Additionally, dorsomorphin dihydrochloride has been shown to enhance bone formation by inhibiting sclerostin, a negative regulator of bone growth. Its specificity and effectiveness make it a significant tool in research aimed at understanding metabolic regulation and developing potential therapeutic strategies for conditions related to energy imbalance and bone health.
| Catalog Number | I013941 |
| CAS Number | 1219168-18-9 |
| Molecular Formula | C₂₄H₂₇Cl₂N₅O |
| Purity | ≥95% |
| Target | AMPKAutophagy |
| Solubility | H2O: ≥ 48 mg/mL; DMSO: 5.2 mg/mL (Need ultrasonic) |
| Storage | under inert gas (nitrogen or Argon) at 2-8°C |
| IUPAC Name | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine;dihydrochloride |
| InChI | InChI=1S/C24H25N5O.2ClH/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20;;/h4-11,16-18H,1-3,12-15H2;2*1H |
| InChIKey | RJDVIJJQKMGPMV-UHFFFAOYSA-N |
| SMILES | C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl |
| Reference | [1]. Zhou G, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 2001 Oct;108(8):1167-74.<br>[2]. Saito S, et al. Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling. PLoS One. 2012;7(9):e45845.<br>[3]. Yu PB, et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 2008 Jan;4(1):33-41.<br>[4]. Zhang DY, et al. Role of autophagy and its molecular mechanisms in mice intestinal tract after severe burn. J Trauma Acute Care Surg. 2017 Oct;83(4):716-724. |
