Dorsomorphin

• CAT Number: I005212
• CAS Number: 866405-64-3
• Molecular Formula: C₂₄H₂₅N₅O
• Molecular Weight: 399.49
• Purity: ≥95%
• Synonyms: 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
• Target: AMPK
• Solubility: 10 mM in DMSO (with heating)； 5 mM in ethanol (with heating)
• Storage: Store at -20C
• IC50: 109 nM (Ki for AMPK)
• InChI: InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2
• InChIKey: XHBVYDAKJHETMP-UHFFFAOYSA-N
• SMILES: C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3

Dorsomorphin（Cat No.:I005212）is a selective inhibitor of AMP-activated protein kinase (AMPK), an essential regulator of cellular energy homeostasis. By inhibiting AMPK, dorsomorphin alters metabolic pathways involved in glucose and lipid metabolism, making it a valuable tool for research in metabolic disorders. It has shown potential in studies related to obesity, diabetes, and cancer, where AMPK’s regulatory role is critical. Additionally, dorsomorphin has been explored for its effects on bone metabolism and development. Its unique mechanism of action provides insights into the complex regulation of cellular energy and metabolic pathways.

Reference

[1]. Jin J, et al. AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. J Lipid Res. 2009 Dec;50(12):2389-97.
[2]. Saito S, et al. Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling. PLoS One. 2012;7(9):e45845.
[3]. Vucicevic L, et al. Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. Autophagy. 2011 Jan;7(1):40-50.