Dorzolomide Hydrochloride

• CAT Number: A000569
• CAS Number: 130693-82-2
• Molecular Formula: C10H17ClN2O4S3
• Molecular Weight: 360.90
• Purity: ≥95%
• Synonyms: MK-507 (L-671152) HCl; Dorzolamide HCl; 130693-82-2; Dorzolomide hydrochloride; Trusopt; Cosopt
• Target: Carbonic Anhydrase
• Storage: -20°C

Dorzolamide Hydrochloride（Cat No.:A000569）is a carbonic anhydrase inhibitor commonly used in ophthalmology to manage intraocular pressure in conditions like glaucoma and ocular hypertension. By inhibiting the enzyme carbonic anhydrase, dorzolamide reduces the production of aqueous humor in the eye, effectively lowering pressure and helping to prevent optic nerve damage. Often administered as an eye drop, it provides a targeted approach with minimal systemic absorption. Dorzolamide is particularly useful in patients seeking alternatives to beta-blockers, offering a well-tolerated and effective solution for long-term intraocular pressure management.

Reference

1:Simultaneous determination of dorzolamide HCL and timolol maleate in eye drops by two different spectroscopic methods. Erk N.J Pharm Biomed Anal. 2002 Apr 15;28(2):391-7. PMID: 11929684
2:The hypotensive efficacy of dorzolamide HCL-timolol maleate 0.50% vs concomitant use of the two drugs. Durante A, Aurilia P, Guarnaccia G, Boles Carenini B.Acta Ophthalmol Scand Suppl. 2000;(232):46. No abstract available. PMID: 11235533