DOTA-GA-maleimide

• CAT Number: I040018
• CAS Number: 1800229-46-2
• Molecular Formula: C25H38N6O11
• Molecular Weight: 598.60
• Purity: ≥95%
• Synonyms: 5-[2-(2,5-dioxopyrrol-1-yl)ethylamino]-5-oxo-2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]pentanoic acid
• InChI: InChI=1S/C25H38N6O11/c32-19(26-5-6-31-20(33)3-4-21(31)34)2-1-18(25(41)42)30-13-11-28(16-23(37)38)9-7-27(15-22(35)36)8-10-29(12-14-30)17-24(39)40/h3-4,18H,1-2,5-17H2,(H,26,32)(H,35,36)(H,37,38)(H,39,40)(H,41,42)
• InChIKey: NOHFVHQBEMKKMB-UHFFFAOYSA-N
• SMILES: C1CN(CCN(CCN(CCN1CC(=O)O)CC(=O)O)C(CCC(=O)NCCN2C(=O)C=CC2=O)C(=O)O)CC(=O)O

DOTA-GA-Maleimide (Cat No.: I040018) is a bifunctional chelator used in radiopharmaceutical and bioconjugation research. It features a DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) moiety for stable metal ion chelation, making it ideal for radiolabeling with isotopes like ^68Ga, ^177Lu, and ^90Y in imaging and targeted therapy. The maleimide group allows site-specific conjugation to thiol-containing biomolecules, such as antibodies and peptides. DOTA-GA-Maleimide is widely applied in cancer diagnostics and theranostics, facilitating the development of novel radiopharmaceuticals for PET and SPECT imaging.

Reference

[1]. Xavier ME, et al., Pre-labelling versus direct labelling of anthrax proteins for imaging of matrix metalloproteinases activity using DOTA-GA. Nucl Med Biol. 2019 May-Jun;72-73:49-54.
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