Dothiepin hydrochloride

• CAT Number: I026472
• CAS Number: 897-15-4
• Molecular Formula: C19H22ClNS
• Molecular Weight: 331.9
• Purity: ≥95%
• Synonyms: Depresym; Dosulepin chloride; Dosulepin hydrochloride; Dosulepin HCl; Dothiepin hydrochloride; Dothiepin HCl; Prothiaden; Xerenal
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
• IUPAC Name: 1-Propanamine, 3-dibenzo(b,e)thiepin-11(6H)-ylidene-N,N-dimethyl-, hydrochloride
• InChI: InChI=1S/C19H21NS.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11+
• InChIKey: XUPZAARQDNSRJB-SJDTYFKWSA-N
• SMILES: Cl.CN(C)CCC=C1/c2ccccc2CSc3ccccc13

Dothiepin hydrochloride (Cat.No:I014009) is a tricyclic antidepressant (TCA) medication used in the treatment of depression and anxiety disorders. It works by increasing the levels of certain neurotransmitters in the brain, thereby improving mood and reducing symptoms of depression.

Reference

1. Lancaster SG, Gonzalez JP. Dothiepin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs. 1989 Jul;38(1):123-47. doi: 10.2165/00003495-198938010-00005. PMID: 2670509.
2. Hayasaka Y, Purgato M, Magni LR, Ogawa Y, Takeshima N, Cipriani A, Barbui C, Leucht S, Furukawa TA. Dose equivalents of antidepressants: Evidence-based recommendations from randomized controlled trials. J Affect Disord. 2015 Jul 15;180:179-84. doi: 10.1016/j.jad.2015.03.021. Epub 2015 Mar 31. PMID: 25911132.
3. Donovan S, Dearden L, Richardson L. The tolerability of dothiepin: a review of clinical studies between 1963 and 1990 in over 13,000 depressed patients. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Nov;18(7):1143-62. doi: 10.1016/0278-5846(94)90117-1. PMID: 7846285.