Dovitinib (TKI258) Lactate monohydrate

• CAT Number: I011833
• CAS Number: 915769-50-5
• Molecular Formula: C24H29FN6O5
• Molecular Weight: 500.52
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: CC(C(=O)O)O.CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=C(C5=C(C=CC=C5F)NC4=O)N.O

Dovitinib (TKI258) Lactate monohydrate is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. Phase 4.

Reference

[1] Trudel S, et al. Blood. 2005, 105(7), 2941-2948.
[2] Huynh H, et al. J Hepatol. 2012, 56(3), 595-601.
[3] Lee SH, et al. Clin Cancer Res. 2005, 11(10), 3633-3641.
[4] Azab AK, et al. Clin Cancer Res, 2011, 17(13), 4389-4399.
[5] Trudel S, et al. Blood, 2005, 105(7), 2941-2948.