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309-29-5-Doxapram Doxapram

Doxapram

For research use only. Not for therapeutic Use.

  • CAT Number: I006523
  • CAS Number: 309-29-5
  • Molecular Formula: C24H30N2O2
  • Molecular Weight: 378.516
  • Purity: ≥95%
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Doxapram (CAT: I006523) is a respiratory stimulant medication used primarily in clinical settings to stimulate breathing. It acts on the central nervous system to increase respiratory drive and respiratory muscle activity, making it useful in situations where there is a need to overcome respiratory depression or hypoventilation. Doxapram is commonly used in the management of respiratory conditions such as post-operative respiratory depression, drug-induced respiratory depression, and respiratory distress in newborns. It is typically administered intravenously or by inhalation. Doxapram works by stimulating the respiratory centers in the brain, leading to increased ventilation and improved oxygenation.


Catalog Number I006523
CAS Number 309-29-5
Synonyms

AHR-619; AHR 619; AHR619; Doxapram; Doxapram hydrochloride, Brand name Dopram, Stimulex or Respiram.;1-ethyl-4- (2-morpholin-4-ylethyl)- 3,3-diphenyl-pyrrolidin-2-one

Molecular Formula C24H30N2O2
Purity ≥95%
Target Potassium Channel
Solubility Soluble in DMSO, not in water
Storage 0 - 4°C for short term or -20 °C for long term
Related CAS 13-07-5 (HCl salt)    
InChI InChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,22H,2,13-19H2,1H3
InChIKey XFDJYSQDBULQSI-UHFFFAOYSA-N
SMILES O=C1N(CC)CC(CCN2CCOCC2)C1(C3=CC=CC=C3)C4=CC=CC=C4
Reference

1: Vliegenthart RJ, Ten Hove CH, Onland W, van Kaam AH. Doxapram Treatment for
Apnea of Prematurity: A Systematic Review. Neonatology. 2017;111(2):162-171. doi:
10.1159/000448941. Epub 2016 Oct 20. Review. PubMed PMID: 27760427; PubMed
Central PMCID: PMC5296887.
<br>

2: Greenstone M, Lasserson TJ. Doxapram for ventilatory failure due to
exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst
Rev. 2003;(1):CD000223. Review. PubMed PMID: 12535393.
<br>

3: Henderson-Smart DJ, Davis PG. Prophylactic doxapram for the prevention of
morbidity and mortality in preterm infants undergoing endotracheal extubation.
Cochrane Database Syst Rev. 2000;(3):CD001966. Review. PubMed PMID: 10908519.
<br>

4: Greenstone M. Doxapram for ventilatory failure due to exacerbations of chronic
obstructive pulmonary disease. Cochrane Database Syst Rev. 2000;(2):CD000223.
Review. Update in: Cochrane Database Syst Rev. 2003;(1):CD000223. PubMed PMID:
10796514.
<br>

5: Henderson-Smart DJ, Steer P. Doxapram versus methylxanthine for apnea in
preterm infants. Cochrane Database Syst Rev. 2000;(2):CD000075. Review. Update
in: Cochrane Database Syst Rev. 2000;(4):CD000075. PubMed PMID: 10796115.
<br>

6: Henderson-Smart DJ, Steer PA. Doxapram treatment for apnea in preterm infants.
Cochrane Database Syst Rev. 2000;(2):CD000074. Review. Update in: Cochrane
Database Syst Rev. 2001;(4):CD000074. PubMed PMID: 10796114.
<br>

7: Bairam A, Boutroy MJ, Vert P. [A respiratory stimulant, doxapram, and its use
in pediatrics]. Arch Fr Pediatr. 1992 May;49(5):469-74. Review. French. PubMed
PMID: 1530447.

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