For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>Doxepin HCl is a tricyclic antidepressant that is marketed worldwide.<br>Target: SSRIs<br>Doxepin inhibits the reuptake of serotonin and norepinephrine and acts as a antagonist at various serotonergic, adrenergic, musacrinic, dopaminergic and histaminergic receptors [1]. In the doxepin-treated patients who completed the study (N = 20, 47.6+/-11.3), medication significantly increased sleep efficiency after acute (night 1, p < or = .001) and subchronic (night 28, p < or = .05) intake compared with the patients who received placebo (N = 20, 47.4+/-16.8 years of age). Doxepin to cause significantly (p < or = .05) better global improvement at the first day of treatment [2].<br></p>
| Catalog Number | I000903 |
| CAS Number | 1229-29-4 |
| Synonyms | 3-(dibenz[b,e]oxepin-11(6H)-ylidene)-N,N-dimethyl-1-propanamine, monohydrochloride |
| Molecular Formula | C19H21NO • HCl |
| Purity | ≥95% |
| Target | Histamine Receptor |
| Solubility | 100 mM in H2O |
| Storage | Store at -20°C |
| InChIKey | MHNSPTUQQIYJOT-CULRIWENSA-N |
| Reference | </br>1:Spectrofluorimetric method for the determination of doxepin hydrochloride in commercial dosage forms. Rahman N, Siddiqui S, Azmi SN.AAPS PharmSciTech. 2009;10(4):1381-7. doi: 10.1208/s12249-009-9341-z. Epub 2009 Nov 21. PMID: 19936937 Free PMC Article</br>2:[Spectrometric study on the interaction of doxepin hydrochloride and fast green and its application]. Wu CK, Feng SL, Fan J.Guang Pu Xue Yu Guang Pu Fen Xi. 2007 Dec;27(12):2490-3. Chinese. PMID: 18330292 </br>3:Novel therapeutic usage of low-dose doxepin hydrochloride. Singh H, Becker PM.Expert Opin Investig Drugs. 2007 Aug;16(8):1295-305. Review. PMID: 17685877 </br>4:Study of the interaction between doxepin hydrochloride and bovine serum albumin by spectroscopic techniques. Kandagal PB, Seetharamappa J, Ashoka S, Shaikh SM, Manjunatha DH.Int J Biol Macromol. 2006 Nov 15;39(4-5):234-9. Epub 2006 Apr 1. PMID: 16678251 </br>5:Extractive spectrophotometric methods for the determination of doxepin hydrochloride in pharmaceutical preparations using titanium (IV) and iron (III) thiocyanate complexes. Misiuk W.Farmaco. 2005 Jan;60(1):61-9. Epub 2004 Dec 19. PMID: 15652371 </br>6:Topical application of doxepin hydrochloride can reduce the symptoms of complex regional pain syndrome: a case report. McCleane G.Injury. 2002 Jan;33(1):88-9. No abstract available. PMID: 11879844 </br>7:Topical application of doxepin hydrochloride, capsaicin and a combination of both produces analgesia in chronic human neuropathic pain: a randomized, double-blind, placebo-controlled study. McCleane G.Br J Clin Pharmacol. 2000 Jun;49(6):574-9. PMID: 10848721 Free PMC Article</br>8:Self-potentiating allergic contact dermatitis caused by doxepin hydrochloride cream. Shelley WB, Shelley ED, Talanin NY.J Am Acad Dermatol. 1996 Jan;34(1):143-4. No abstract available. PMID: 8543684 </br>9:High-performance liquid chromatographic determination of (Z)- and (E)-doxepin hydrochloride isomers. Whall TJ, Dokladalova J.J Pharm Sci. 1979 Nov;68(11):1454-6. PMID: 512900 </br>10:Doxepin hydrochloride. Hollister LE.Ann Intern Med. 1974 Sep;81(3):360-3. No abstract available. PMID: 4604347 |
