Doxepin Hydrochloride

• CAT Number: I000903
• CAS Number: 1229-29-4
• Molecular Formula: C19H21NO • HCl
• Molecular Weight: 315.81
• Purity: ≥95%
• Synonyms: 3-(dibenz[b,e]oxepin-11(6H)-ylidene)-N,N-dimethyl-1-propanamine, monohydrochloride
• Target: Neuronal Signaling
• Solubility: 100 mM in H2O
• Storage: Store at -20°C
• IUPAC Name: (3E)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine;hydrochloride
• InChI: InChI=1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11+
• InChIKey: MHNSPTUQQIYJOT-CULRIWENSA-N
• SMILES: CN(C)CC/C=C/1\C2=CC=CC=C2COC3=CC=CC=C31.Cl

Doxepin Hydrochloride(CAT: I000903) is a tricyclic antidepressant (TCA) primarily used to treat major depressive disorder, anxiety disorders, and insomnia. It functions by inhibiting the reuptake of serotonin (5-HT) and norepinephrine (NE), enhancing neurotransmitter levels in the brain to improve mood and reduce anxiety. Additionally, Doxepin acts as a potent histamine H₁ receptor antagonist, contributing to its sedative effects, making it effective in managing chronic insomnia and pruritus (itching). Doxepin Hydrochloride is extensively studied in neuropharmacology and psychiatric research for its therapeutic potential in mood regulation, sleep disorders, and dermatological conditions.