Doxorubicin.HCl

• CAT Number: I002864
• CAS Number: 25316-40-9
• Molecular Formula: C27H29NO11 .HCl
• Molecular Weight: 579.98
• Purity: ≥95%
• Synonyms: (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride
• Target: Topoisomerase
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: 3 years -20C powder
• InChI: InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
• InChIKey: MWWSFMDVAYGXBV-RUELKSSGSA-N
• SMILES: CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O.Cl

Doxorubicin Hydrochloride (Cat No.:I002864) is an anthracycline chemotherapy drug commonly used in the treatment of various cancers, including breast cancer, lung cancer, and leukemia. It exerts its cytotoxic effects by intercalating into DNA, inhibiting DNA replication and transcription, and inducing DNA damage. Doxorubicin also generates free radicals that further contribute to its antitumor activity. It is typically administered intravenously and has a broad spectrum of antitumor activity. However, doxorubicin can cause side effects such as cardiotoxicity, myelosuppression, and gastrointestinal toxicity. The hydrochloride salt form of doxorubicin is commonly used for clinical applications due to its improved stability and solubility compared to the free base form.

Overview of Clinical Research

Doxorubicin is a DNA intercalator and a Type II DNA topoisomerase inhibitor. There is no new molecular entity and orphan drug status. 

Reference

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[2]. Patel S, Sprung AU, Keller BA, et al. Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: implications for the mechanisms of doxorubicin action and cytotoxicity. Mol Pharmacol. 1997 Oct;52(4):658-66.
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[4]. Pourquier P, Montaudon D, Huet S, et al. Doxorubicin-induced alterations of c-myc and c-jun gene expression in rat glioblastoma cells: role of c-jun in drug resistance and cell death. Biochem Pharmacol. 1998 Jun 15;55(12):1963-71.
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