Doxycycline hyclate

• CAT Number: A000602
• CAS Number: 24390-14-5
• Molecular Formula: C₂₂H₂₄N₂O₈.HCl
• Molecular Weight: 480.90
• Purity: ≥95%
• Synonyms: Vivox; Doxy-Lemmon; Doxychel Hyclate; Atridox; Periostat
• Target: Metabolic Enzyme/Protease
• Storage: -20°C
• IUPAC Name: (4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
• InChI: InChI=1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25-27,30,32H,1-3H3,(H2,23,31)/t7-,10+,14+,15-,17-,22-/m0/s1
• InChIKey: SGKRLCUYIXIAHR-AKNGSSGZSA-N
• SMILES: C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O

Doxycycline Hyclate（Cat No.:A000602）is a broad-spectrum tetracycline antibiotic used to treat various bacterial infections, including respiratory tract infections, acne, and sexually transmitted diseases. It inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing the addition of amino acids to growing peptide chains. Doxycycline Hyclate is also effective against certain protozoal infections and is used in malaria prophylaxis. Its long half-life and excellent oral absorption make it a preferred choice for many infections. Additionally, it is widely studied for its anti-inflammatory and antimicrobial resistance-modulating properties.

Reference

1: Phaechamud T, Setthajindalert O. Cholesterol in situ forming gel loaded with
doxycycline hyclate for intra-periodontal pocket delivery. Eur J Pharm Sci. 2017
Mar 1;99:258-265. doi: 10.1016/j.ejps.2016.12.023. Epub 2016 Dec 24. PubMed PMID:
28027940.

2: Phaechamud T, Chanyaboonsub N, Setthajindalert O. Doxycycline hyclate-loaded
bleached shellac in situ forming microparticle for intraperiodontal pocket local
delivery. Eur J Pharm Sci. 2016 Oct 10;93:360-70. doi:
10.1016/j.ejps.2016.08.034. Epub 2016 Aug 20. PubMed PMID: 27552903.

3: Dhal C, Ahmad FJ, Chauhan A, Jyothi M, Singh RM, Saini PK, Mathur SC, Singh
GN. Quality by Design Approach for Simultaneous Estimation of Doxycycline Hyclate
and Curcumin by RP-HPLC Method. Indian J Pharm Sci. 2015 Nov-Dec;77(6):723-8.
PubMed PMID: 26997700; PubMed Central PMCID: PMC4778232.

4: Arciniegas Ruiz SM, Gutiérrez Olvera L, Bernad Bernad MJ, Caballero Chacón
Sdel C, Vargas Estrada D. Comparative pharmacokinetics of a new oral long-acting
formulation of doxycycline hyclate: A canine clinical trial. Eur J Pharm Sci.
2015 Dec 1;80:9-15. doi: 10.1016/j.ejps.2015.09.012. Epub 2015 Sep 21. PubMed
PMID: 26393684.

5: Kopytynska-Kasperczyk A, Dobrzynski P, Pastusiak M, Jarzabek B, Prochwicz W.
Local delivery system of doxycycline hyclate based on ε-caprolactone copolymers
for periodontitis treatment. Int J Pharm. 2015 Aug 1;491(1-2):335-44. doi:
10.1016/j.ijpharm.2015.06.034. Epub 2015 Jul 2. PubMed PMID: 26143233.

6: Ruiz SM, Olvera LG, Chacón Sdel C, Estrada DV. Pharmacokinetics of an oral
extended-release formulation of doxycycline hyclate containing acrylic acid and
polymethacrylate in dogs. Am J Vet Res. 2015 Apr;76(4):367-72. doi:
10.2460/ajvr.76.4.367. PubMed PMID: 25815578.

7: Xia JL, Wang LQ, Wu LL, Huang QB. Doxycycline hyclate protects
lipopolysaccharide-induced endothelial barrier dysfunction by inhibiting the
activation of p38 mitogen-activated protein kinase. Biol Pharm Bull.
2014;37(12):1882-90. PubMed PMID: 25451837.

8: Kogawa AC, Zoppi A, Quevedo MA, Nunes Salgado HR, Longhi MR. Increasing
doxycycline hyclate photostability by complexation with β-cyclodextrin. AAPS
PharmSciTech. 2014 Oct;15(5):1209-17. doi: 10.1208/s12249-014-0150-7. Epub 2014
Jun 3. PubMed PMID: 24889734; PubMed Central PMCID: PMC4179669.

9: Vijayabala GS. Single application of topical doxycycline hyclate in the
management of recurrent aphthous stomatitis: reply to remarks. Oral Surg Oral Med
Oral Pathol Oral Radiol. 2014 Apr;117(4):533-4. doi: 10.1016/j.oooo.2013.12.411.
Epub 2014 Jan 3. PubMed PMID: 24556496.

10: Shoor H, Pai KM. Single application of topical doxycycline hyclate in the
management of recurrent aphthous stomatitis: remarks. Oral Surg Oral Med Oral
Pathol Oral Radiol. 2014 Apr;117(4):533. doi: 10.1016/j.oooo.2013.11.501. Epub
2014 Jan 3. PubMed PMID: 24480145.