Doxycycline monohydrate

• CAT Number: M085028
• CAS Number: 17086-28-1
• Molecular Formula: C22H24N2O8 H
• Molecular Weight: 462.46
• Purity: ≥95%
• Storage: -80°C
• IUPAC Name: (4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrate
• InChI: InChI=1S/C22H24N2O8.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25-27,30,32H,1-3H3,(H2,23,31);1H2/t7-,10+,14+,15-,17-,22-;/m0./s1
• InChIKey: FZKWRPSUNUOXKJ-CVHRZJFOSA-N
• SMILES: C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O

Doxycycline Monohydrate（Cat No.:M085028）is a broad-spectrum tetracycline antibiotic widely used to treat various bacterial infections. It inhibits protein synthesis by binding to the 30S ribosomal subunit, making it effective against gram-positive and gram-negative bacteria. Doxycycline monohydrate is commonly used to treat respiratory infections, acne, urinary tract infections, and sexually transmitted diseases. Its extended half-life allows for less frequent dosing compared to other tetracyclines. Additionally, doxycycline has anti-inflammatory properties, making it a useful option in conditions like rosacea and certain inflammatory diseases.

Reference

Hydrogenolysis studies in the tetracycline series – 6-Deoxytetracyclines. Stephens C.R. et al. J. Am. Chem. Soc. 1958, 80, 5324.Comparison of in vitro activity and clinical pharmacology of doxycycline with other tetracyclines. Rosenblatt J.E. et al. Antimicrob. Agents Chemother. 1966, 6, 134.