For research use only. Not for therapeutic Use.
DP00477 is a potent IDO1 (indoleamine 2,3-dioxygenase 1) inhibitor with an IC50 value of 7.0 µM. DP00477 has the potential for the research of cancer[1].
DP00477 inhibits IDO1 activity with IC50s of 71, 6.3 µM when 5 mM GSH or 0.01% Triton-X is added, respectively[1].
| Catalog Number | I042315 |
| CAS Number | 169120-56-3 |
| Synonyms | 3-(2-chloroanilino)-2-cyano-3-sulfanylidene-N-[3-(trifluoromethyl)phenyl]propanamide |
| Molecular Formula | C17H11ClF3N3OS |
| Purity | ≥95% |
| InChI | InChI=1S/C17H11ClF3N3OS/c18-13-6-1-2-7-14(13)24-16(26)12(9-22)15(25)23-11-5-3-4-10(8-11)17(19,20)21/h1-8,12H,(H,23,25)(H,24,26) |
| InChIKey | JBTPUMQIJZGWRT-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C(=C1)NC(=S)C(C#N)C(=O)NC2=CC=CC(=C2)C(F)(F)F)Cl |
| Reference | [1]. Röhrig UF, et al. Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. Eur J Med Chem. 2014 Sep 12;84:284-301. |
