DPA-714

• CAT Number: R072249
• CAS Number: 958233-07-3
• Molecular Formula: C22H27FN4O2
• Molecular Weight: 398.47
• Purity: ≥95%
• Synonyms: N,N-Diethyl-2-(2-(4-(2-fluoro-1-ethoxy)phenyl)- 5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide
• IUPAC Name: N,N-diethyl-2-[2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]acetamide
• InChI: InChI=1S/C22H27FN4O2/c1-5-26(6-2)20(28)14-19-21(17-7-9-18(10-8-17)29-12-11-23)25-27-16(4)13-15(3)24-22(19)27/h7-10,13H,5-6,11-12,14H2,1-4H3
• InChIKey: FLZZFWBNYJNHMY-UHFFFAOYSA-N
• SMILES: CCN(CC)C(=O)CC1=C2N=C(C=C(N2N=C1C3=CC=C(C=C3)OCCF)C)C

DPA-714 is a potent and selective ligand for the translocator protein (TSPO), commonly used in neuroinflammation research and imaging studies. It binds with high affinity to TSPO, which is overexpressed in activated microglia and macrophages, making it a valuable tool for visualizing and quantifying neuroinflammatory processes using PET imaging. DPA-714 is instrumental in studying neurological disorders, such as Alzheimer’s disease and multiple sclerosis, offering insights into disease progression and the effects of therapeutic interventions.