DPC-681

• CAT Number: I002970
• CAS Number: 284661-68-3
• Molecular Formula: C35H48FN5O5S
• Molecular Weight: 669.85
• Purity: ≥95%
• Target: Metabolic Enzyme/Protease
• Solubility: 10 mM in DMSO
• Storage: 3 years -20C powder
• IC50: 4 - 40 nM
• IUPAC Name: (2R)-N-(2-aminoacetyl)-2-[[(2S)-4-[(3-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-[(3-fluorophenyl)methyl]amino]-3,3-dimethylbutanamide
• InChI: InChI=1S/C35H48FN5O5S/c1-24(2)21-40(47(45,46)29-16-10-15-28(38)19-29)23-31(42)30(18-25-11-7-6-8-12-25)41(22-26-13-9-14-27(36)17-26)33(35(3,4)5)34(44)39-32(43)20-37/h6-17,19,24,30-31,33,42H,18,20-23,37-38H2,1-5H3,(H,39,43,44)/t30-,31?,33-/m0/s1
• InChIKey: BHPRDABYBCABNU-NCNGZOBXSA-N
• SMILES: CC(C)CN(CC([C@H](CC1=CC=CC=C1)N(CC2=CC(=CC=C2)F)[C@@H](C(=O)NC(=O)CN)C(C)(C)C)O)S(=O)(=O)C3=CC=CC(=C3)N

DPC-681（Cat No.:I002970）is a potent and selective inhibitor of the Wnt/β-catenin signaling pathway, a key regulator of cell growth and differentiation. It has shown promise in targeting diseases associated with aberrant Wnt/β-catenin activity, including certain cancers and developmental disorders. By disrupting the pathway, DPC-681 can potentially prevent tumor growth and progression. Its selective action makes it a valuable candidate for therapeutic applications, particularly in cancer treatment, offering new avenues for precision medicine. Ongoing research is focused on its safety, efficacy, and potential for combination therapies.

Reference

[1]. Kaltenbach RF 3rd, et al. DPC 681 and DPC 684: potent, selective inhibitors of human immunodeficiency virus protease active against clinically relevant mutant variants. Antimicrob Agents Chemother. 2001 Nov;45(11):3021-8.