For research use only. Not for therapeutic Use.
DPQ is a potent PARP-1 inhibitor. DPQ can reduce the N-methyl-d-aspartate (NMDA)-induced PARP activation, restoring ATP to near control levels and significantly attenuating neuronal injury in the severe NMDA exposure model. DPQ can be used for researching neuroprotection[1].
| Catalog Number | R016186 |
| CAS Number | 129075-73-6 |
| Synonyms | 5-(4-piperidin-1-ylbutoxy)-3,4-dihydro-2H-isoquinolin-1-one |
| Molecular Formula | C18H26N2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21) |
| InChIKey | RVOUDNBEIXGHJY-UHFFFAOYSA-N |
| SMILES | C1CCN(CC1)CCCCOC2=CC=CC3=C2CCNC3=O |
| Reference | [1]. Meli E, et al. Differential role of poly(ADP-ribose) polymerase-1in apoptotic and necrotic neuronal death induced by mild or intense NMDA exposure in vitro. Mol Cell Neurosci. 2004;25(1):172-180. |
