DPTIP hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: I047694
  • CAS Number: 2361799-64-4
  • Molecular Formula: C21H18N2O3S.HCl
  • Molecular Weight: 414.91
  • Purity: ≥95%
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DPTIP hydrochloride is a potent selective, metabolically stable, and brain-penetrant neutral sphingomyelinase 2 (nSMase2) inhibitor with an IC50 value of 30 nM.
KEYWORDS: DPTIP hydrochloride | Supplier | N-SMase2 inhibitor | CAS [2361799-64-4] | [351353-48-5] | Sphingolipid | PDE | Inhibitor | Enzymes | Brain injury


Catalog Number I047694
CAS Number 2361799-64-4
Molecular Formula C21H18N2O3S.HCl
Purity ≥95%
IUPAC Name 2,6-dimethoxy-4-(4-phenyl-5-thiophen-2-yl-1H-imidazol-2-yl)phenol;hydrochloride
InChI InChI=1S/C21H18N2O3S.ClH/c1-25-15-11-14(12-16(26-2)20(15)24)21-22-18(13-7-4-3-5-8-13)19(23-21)17-9-6-10-27-17;/h3-12,24H,1-2H3,(H,22,23);1H
SMILES COC1=CC(=CC(=C1O)OC)C2=NC(=C(N2)C3=CC=CS3)C4=CC=CC=C4.Cl
Reference

C Rojas et al. DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Sci Rep. 2018 Dec 7;8(1):17715.

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