For research use only. Not for therapeutic Use.
DPTN is a highly potent and moderately selective human and rat A3AR antagonist with Ki values of 0.36 nM and 1.6 nM for hA3AR and rA3AR receptors, respectively.
KEYWORDS: DPTN | Supplier | A3 antagonist | CAS [224040-19-1] | [325767-87-1] | Adenosine | A3 | Antagonist | Receptors | Anti-asthmatic | Glaucoma | Neuroprotection
| Catalog Number | I047702 |
| CAS Number | 224040-19-1 |
| Molecular Formula | C22H18N4OS |
| Purity | ≥95% |
| IUPAC Name | N-[4-(3,5-dimethylphenyl)-5-pyridin-4-yl-1,3-thiazol-2-yl]pyridine-3-carboxamide |
| InChI | InChI=1S/C22H18N4OS/c1-14-10-15(2)12-18(11-14)19-20(16-5-8-23-9-6-16)28-22(25-19)26-21(27)17-4-3-7-24-13-17/h3-13H,1-2H3,(H,25,26,27) |
| SMILES | CC1=CC(=CC(=C1)C2=C(SC(=N2)NC(=O)C3=CN=CC=C3)C4=CC=NC=C4)C |
| Reference | S Miwatashi et al. Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as selective adenosine A3 antagonists. Chem Pharm Bull (Tokyo). 2008 Aug;56(8):1126-37. ZG Gao et al. Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists. Purinergic Signal. 2021 Dec;17(4):737-746. |
