DREADD agonist 21

• CAT Number: I004101
• CAS Number: 56296-18-5
• Molecular Formula: C17H18N4
• Molecular Weight: 278.4
• Purity: ≥95%
• Synonyms: 11-​(1-​piperazinyl)​-​5H-​​dibenzo[b,​e]​​[1,​4]​​diazepine
• Target: Neuronal Signaling
• Solubility: DMSO: ≥ 78 mg/mL
• Storage: -20°C
• InChIKey: JCBYXNSOLUVGTF-UHFFFAOYSA-N

DREADD Agonist 21 (Cat No.: I004101) is a selective and potent ligand used to activate Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), enabling precise control of neuronal and cellular activity. Unlike clozapine-N-oxide (CNO), it offers improved brain penetrance and minimal off-target effects, making it ideal for chemogenetic studies in neuroscience. DREADD Agonist 21 is widely used in behavioral, neurological, and pharmacological research to modulate GPCR signaling with high specificity, advancing the understanding of neural circuits and therapeutic targeting.

Reference

[1]. Chen X, et al. The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. ACS Chem Neurosci. 2015 Mar 18;6(3):476-84.