DRP1i27 dihydrochloride

• CAT Number: I040824
• Molecular Formula: C20H28Cl2N6O
• Molecular Weight: 439.38
• Purity: ≥95%
• Synonyms: (1S,5R)-3-[(5-methyl-1H-imidazol-4-yl)methyl]-6-[[5-(1H-pyrazol-5-yl)furan-2-yl]methyl]-3,6-diazabicyclo[3.2.2]nonane;dihydrochloride
• InChI: InChI=1S/C20H26N6O.2ClH/c1-14-19(22-13-21-14)12-25-8-15-2-3-16(10-25)26(9-15)11-17-4-5-20(27-17)18-6-7-23-24-18;;/h4-7,13,15-16H,2-3,8-12H2,1H3,(H,21,22)(H,23,24);2*1H/t15-,16+;;/m0../s1
• InChIKey: AIKSENSXOKTNOB-SLAHTUFOSA-N
• SMILES: CC1=C(N=CN1)CN2CC3CCC(C2)N(C3)CC4=CC=C(O4)C5=CC=NN5.Cl.Cl

DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 dihydrochloride binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 dihydrochloride targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury[1].
DRP1i27 (0-50 μM) dihydrochloride directly binds to and inhibits GTPase activity of human Drp1[1].
DRP1i27 (0-50 μM) dihydrochloride is able to increase cellular networks of mitochondria in human and mouse fibroblasts in a Drp1-dependent manner[1].
DRP1i27 dihydrochloride has a binding affinity of 286 μM in the SPR assay and a KD value of 190 μM via the MST assay[1].

Reference

[1]. Rosdah AA, et al. A novel small molecule inhibitor of human Drp1. Sci Rep. 2022 Dec 13;12(1):21531.
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