For research use only. Not for therapeutic Use.
DS-3801b（Cat No.:I043889）is a novel, selective small molecule inhibitor targeting fibroblast growth factor receptor 1 (FGFR1), a receptor tyrosine kinase involved in cell growth, survival, and differentiation. Aberrant FGFR signaling is associated with various cancers, including lung, breast, and gastric cancers. DS-3801b is designed to block FGFR1 activation, thereby inhibiting tumor cell proliferation and angiogenesis. It has shown potential in preclinical studies for treating cancers driven by FGFR1 mutations or amplifications. Researchers use DS-3801b to explore targeted therapies for cancer treatment and the role of FGFR signaling in tumor progression.
| CAS Number | 1369412-66-7 |
| Synonyms | 4-[3-(hydroxymethyl)phenoxy]-N-methyl-N-[3-methyl-4-[[(3S)-3-methylpiperazin-1-yl]methyl]phenyl]cyclohexane-1-carboxamide |
| Molecular Formula | C28H39N3O3 |
| Purity | ≥95% |
| IUPAC Name | 4-[3-(hydroxymethyl)phenoxy]-N-methyl-N-[3-methyl-4-[[(3S)-3-methylpiperazin-1-yl]methyl]phenyl]cyclohexane-1-carboxamide |
| InChI | InChI=1S/C28H39N3O3/c1-20-15-25(10-7-24(20)18-31-14-13-29-21(2)17-31)30(3)28(33)23-8-11-26(12-9-23)34-27-6-4-5-22(16-27)19-32/h4-7,10,15-16,21,23,26,29,32H,8-9,11-14,17-19H2,1-3H3/t21-,23?,26?/m0/s1 |
| InChIKey | XCVUPJBVKKACQB-ZMWWRJPQSA-N |
| SMILES | CC1CN(CCN1)CC2=C(C=C(C=C2)N(C)C(=O)C3CCC(CC3)OC4=CC=CC(=C4)CO)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
