For research use only. Not for therapeutic Use.
DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC50 of 90 nM[1].
| Catalog Number | I018109 |
| CAS Number | 2376334-75-5 |
| Synonyms | 5-cyclohexyl-3,3-dimethyl-1-[4-[2-(oxan-4-ylamino)ethylamino]phenyl]-2-oxo-1,4-benzodiazepine-8-carbonitrile |
| Molecular Formula | C31H39N5O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C31H39N5O2/c1-31(2)30(37)36(26-11-9-24(10-12-26)33-16-17-34-25-14-18-38-19-15-25)28-20-22(21-32)8-13-27(28)29(35-31)23-6-4-3-5-7-23/h8-13,20,23,25,33-34H,3-7,14-19H2,1-2H3 |
| InChIKey | SOYFWNNFRLABJC-UHFFFAOYSA-N |
| SMILES | CC1(C(=O)N(C2=C(C=CC(=C2)C#N)C(=N1)C3CCCCC3)C4=CC=C(C=C4)NCCNC5CCOCC5)C |
| Reference | [1]. Arai Y, et al. Discovery of novel PTHR1 antagonists: Design, synthesis, and structure activity relationships. Bioorg Med Chem Lett. 2019 Sep 15;29(18):2613-2616. |
