For research use only. Not for therapeutic Use.
DS17 is a molecular glue that acts as a potent degrader of cyclin K, with an EC50 of 13 nM. DS17 plays an important role in cancer research[1].
| Catalog Number | I040104 |
| Synonyms | (2R)-2-[[6-[(5,6-dichloro-1H-benzimidazol-2-yl)methylamino]-9-propan-2-ylpurin-2-yl]amino]butan-1-ol |
| Molecular Formula | C20H24Cl2N8O |
| Purity | ≥95% |
| InChI | InChI=1S/C20H24Cl2N8O/c1-4-11(8-31)25-20-28-18(17-19(29-20)30(9-24-17)10(2)3)23-7-16-26-14-5-12(21)13(22)6-15(14)27-16/h5-6,9-11,31H,4,7-8H2,1-3H3,(H,26,27)(H2,23,25,28,29)/t11-/m1/s1 |
| InChIKey | NIAQZRDKVVUEMV-LLVKDONJSA-N |
| SMILES | CCC(CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=NC4=CC(=C(C=C4N3)Cl)Cl |
| Reference | [1]. Zuzanna Kozicka, et al. Design principles for cyclin K molecular glue degraders. Nat Chem Zuzanna Kozicka, et al. Design principles for cyclin K molecular glue degraders. Nat Chem Biol. 2024 Jan;20(1):93-102. Biol. 2024 Jan;20(1):93-102. |
