For research use only. Not for therapeutic Use.
DS20362725 is an estrogen-related receptor α (ERRα) agonist. DS20362725 inhibits the binding between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain (LBD; 1.2 μM) with an IC50 value of 0.6 μM. DS20362725 can be used for the research of metabolic disorders, including type 2 diabetes mellitus (T2DM)[1].
DS20362725 (compound 3d; 0.002, 0.006, 0.017, 0.051, 0.015, 0.046, 1.4, 4.2, 12.5 μg/mL; 18 h) activates the transcriptional activity of full-length ERRα in MG63 cells with an EC50 of 1.1 μM[1].
| Catalog Number | I045202 |
| CAS Number | 2735803-20-8 |
| Synonyms | 2-tert-butyl-4-(2,3-dimethylbenzimidazol-5-yl)oxyphenol |
| Molecular Formula | C19H22N2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H22N2O2/c1-12-20-16-8-6-14(11-17(16)21(12)5)23-13-7-9-18(22)15(10-13)19(2,3)4/h6-11,22H,1-5H3 |
| InChIKey | LQWRSCHPPDJXLC-UHFFFAOYSA-N |
| SMILES | CC1=NC2=C(N1C)C=C(C=C2)OC3=CC(=C(C=C3)O)C(C)(C)C |
| Reference | [1]. Shinozuka T, et al. Discovery of a Novel Class of ERRα Agonists. ACS Med Chem Lett. 2021 Apr 21;12(5):817-821. |
