For research use only. Not for therapeutic Use.
DS44960156 is a selective Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor, with IC50 values of 1.6 μM and >30 μM for MTHFD2 and MTHFD1, respectively[1].
| Catalog Number | I045435 |
| CAS Number | 2361327-08-2 |
| Synonyms | 4-(5-oxo-2,4-dihydro-1H-chromeno[3,4-c]pyridine-3-carbonyl)benzoic acid |
| Molecular Formula | C20H15NO5 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H15NO5/c22-18(12-5-7-13(8-6-12)19(23)24)21-10-9-14-15-3-1-2-4-17(15)26-20(25)16(14)11-21/h1-8H,9-11H2,(H,23,24) |
| InChIKey | OXUKTNZACAKVRG-UHFFFAOYSA-N |
| SMILES | C1CN(CC2=C1C3=CC=CC=C3OC2=O)C(=O)C4=CC=C(C=C4)C(=O)O |
| Reference | [1]. Junya Kawai, et al. Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold. ACS Med Chem Lett. 2019 May 24;10(6):893-898. |
