DS45500853

• CAT Number: I047645
• CAS Number: 2735803-28-6
• Molecular Formula: C18H20O3
• Molecular Weight: 284.35
• Purity: ≥95%
• IUPAC Name: 1-[4-(3-tert-butyl-4-hydroxyphenoxy)phenyl]ethanone
• InChI: InChI=1S/C18H20O3/c1-12(19)13-5-7-14(8-6-13)21-15-9-10-17(20)16(11-15)18(2,3)4/h5-11,20H,1-4H3
• SMILES: CC(=O)C1=CC=C(C=C1)OC2=CC(=C(C=C2)O)C(C)(C)C

DS45500853 is an ERRα agonist with an IC50 value of 0.80 μM (for binding between F-RIP140 and GST-ERRα) and an ERRα reporter EC50 value of 5.4 μM. DS45500853 is devoid of PPAR γ transcriptional activity.
KEYWORDS: DS45500853 | Supplier | ERRα agonist | DS 45500853 | DS-45500853 | CAS [2735803-28-6] | Estrogen | ERRα | Agonist | Receptors | Metabolic disorder | Type 2 diabetes mellitus | T2DM

Reference

T Shinozuka et al. Discovery of a Novel Class of ERRα Agonists. ACS Med Chem Lett. 2021 Apr 21;12(5):817-821.