DSHS00884

For research use only, not for therapeutic use.

  • CAT Number: I017652
  • CAS Number: 675104-49-1
  • Molecular Formula: C₁₂H₁₂N₄O₂S₂
  • Molecular Weight: 308.38
  • Purity: ≥95%
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DSHS00884 (Cat No.:I017652) is a highly potent inhibitor of human papillomavirus E6 protein, with an IC50 of 10 μM. It effectively stabilizes p53 levels in HPV-positive cells by blocking E6-mediated degradation of p53, with an IC50 range of 2.5-25 μM. DSHS00884 has the potential as a therapeutic agent in HPV-associated cancers by restoring p53 tumor suppressor function and inducing apoptosis.


Catalog Number I017652
CAS Number 675104-49-1
Molecular Formula C₁₂H₁₂N₄O₂S₂
Purity ≥95%
IUPAC Name 3-[(2-nitrophenyl)sulfanylmethyl]-4-prop-2-enyl-1H-1,2,4-triazole-5-thione
InChI InChI=1S/C12H12N4O2S2/c1-2-7-15-11(13-14-12(15)19)8-20-10-6-4-3-5-9(10)16(17)18/h2-6H,1,7-8H2,(H,14,19)
InChIKey VWFIHGWHMXSTAO-UHFFFAOYSA-N
SMILES C=CCN1C(=NNC1=S)CSC2=CC=CC=C2[N+](=O)[O-]
Reference

[1]. Malecka KA, et al. Identification and characterization of small molecule human papillomavirus E6 inhibitors. ACS Chem Biol. 2014 Jul 18;9(7):1603-12.

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