DSSeb Crosslinker

• CAT Number: I014348
• CAS Number: 23024-29-5
• Molecular Formula: C18H24N2O8
• Molecular Weight: 396.39
• Purity: ≥95%
• Synonyms: DSSeb Crosslinker, DSSeb Cross linker, DSSeb Cross-linker;Disuccinimidyl sebacate
• Solubility: Soluble in DMSO
• IUPAC Name: C1CC(=O)N(C1=O)OC(=O)CCCCCCCCC(=O)ON2C(=O)CCC2=O
• InChI: InChI=1S/C18H24N2O8/c21-13-9-10-14(22)19(13)27-17(25)7-5-3-1-2-4-6-8-18(26)28-20-15(23)11-12-16(20)24/h1-12H2
• InChIKey: XPKIVYVYXKPGBP-UHFFFAOYSA-N
• SMILES: O=C(ON1C(CCC1=O)=O)CCCCCCCCC(ON2C(CCC2=O)=O)=O

DSSeb Crosslinker(CAT: I014348) is a homobifunctional, amine-reactive crosslinker commonly used in bioconjugation and protein-protein interaction studies. It contains two N-hydroxysuccinimide (NHS) ester groups that selectively react with primary amines on lysine residues or N-termini of proteins, forming stable amide bonds. DSSeb features a longer, flexible aliphatic spacer arm compared to standard crosslinkers, allowing for efficient crosslinking of proteins and biomolecules at greater distances. This property makes it highly valuable in structural biology and proteomics research, where it aids in mapping protein interactions and stabilizing protein complexes for analysis.