For research use only. Not for therapeutic Use.
DSSeb Crosslinker, or Disuccinimidyl sebacate, is a homobifunctional crosslinking reagent which is cell membrane permeable. DSSeb Crosslinker is useful in protein crosslinking and making antibody drug conjugates (ADCs).
| Catalog Number | I014348 |
| CAS Number | 23024-29-5 |
| Synonyms | DSSeb Crosslinker, DSSeb Cross linker, DSSeb Cross-linker;Disuccinimidyl sebacate |
| Molecular Formula | C18H24N2O8 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| InChI | InChI=1S/C18H24N2O8/c21-13-9-10-14(22)19(13)27-17(25)7-5-3-1-2-4-6-8-18(26)28-20-15(23)11-12-16(20)24/h1-12H2 |
| InChIKey | XPKIVYVYXKPGBP-UHFFFAOYSA-N |
| SMILES | O=C(ON1C(CCC1=O)=O)CCCCCCCCC(ON2C(CCC2=O)=O)=O |
| Reference | </br>1: Heck T, Faccio G, Richter M, Thöny-Meyer L. Enzyme-catalyzed protein crosslinking. Appl Microbiol Biotechnol. 2013 Jan;97(2):461-75. doi: 10.1007/s00253-012-4569-z. Epub 2012 Nov 25. Review. PubMed PMID: 23179622; PubMed Central PMCID: PMC3546294.</br>2: Reddy N, Reddy R, Jiang Q. Crosslinking biopolymers for biomedical applications. Trends Biotechnol. 2015 Jun;33(6):362-9. doi: 10.1016/j.tibtech.2015.03.008. Epub 2015 Apr 14. Review. PubMed PMID: 25887334.</br>3: Movahedi A, Lundin A, Kann N, Nydén M, Moth-Poulsen K. Cu(I) stabilizing crosslinked polyethyleneimine. Phys Chem Chem Phys. 2015 Jul 28;17(28):18327-36. doi: 10.1039/c5cp02198g. PubMed PMID: 26104912.</br>4: Reinitz SD, Currier BH, Levine RA, Van Citters DW. Crosslink density, oxidation and chain scission in retrieved, highly cross-linked UHMWPE tibial bearings. Biomaterials. 2014 May;35(15):4436-40. doi: 10.1016/j.biomaterials.2014.02.019. Epub 2014 Mar 1. PubMed PMID: 24589360.</br>5: Javadi MA, Feizi S. Sterile Keratitis following Collagen Crosslinking. J Ophthalmic Vis Res. 2014 Oct-Dec;9(4):510-3. doi: 10.4103/2008-322X.150832. PubMed PMID: 25709779; PubMed Central PMCID: PMC4329714. </br> </br> |
