For research use only. Not for therapeutic Use.
DTP3 inhibitor（Cat No.:I026580）is a selective dual inhibitor that targets the interaction between the transcription factor NF-κB and the anti-apoptotic protein GADD45β/MKK7, disrupting this complex to trigger apoptosis in cancer cells. It is particularly effective in targeting multiple myeloma, where NF-κB signaling plays a crucial role in cell survival and proliferation. By blocking this pathway, DTP3 induces selective cancer cell death without affecting healthy cells. This makes it a promising compound in cancer research, offering a novel therapeutic approach for treating malignancies driven by aberrant NF-κB signaling.
| Catalog Number | I026580 |
| CAS Number | 1809784-29-9 |
| Synonyms | DTP3; DTP-3; DTP 3; |
| Molecular Formula | C26H35N7O5 |
| Purity | 98% |
| Solubility | To be determined |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (2R)-2-[[(2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(2R)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide |
| InChI | InChI=1S/C26H35N7O5/c1-16(34)31-22(15-18-9-11-19(35)12-10-18)25(38)32-20(8-5-13-30-26(28)29)24(37)33-21(23(27)36)14-17-6-3-2-4-7-17/h2-4,6-7,9-12,20-22,35H,5,8,13-15H2,1H3,(H2,27,36)(H,31,34)(H,32,38)(H,33,37)(H4,28,29,30)/t20-,21-,22-/m1/s1 |
| InChIKey | AOUZPXZGMZUQQS-YPAWHYETSA-N |
| SMILES | CC(=O)N[C@H](CC1=CC=C(C=C1)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)N |
| Reference | Tornatore L, Capece D, D’Andrea D, Begalli F, Verzella D, Bennett J, Acton G, Campbell EA, Kelly J, Tarbit M, Adams N, Bannoo S, Leonardi A, Sandomenico A, Raimondo D, Ruvo M, Chambery A, Oblak M, Al-Obaidi MJ, Kaczmarski RS, Gabriel I, Oakervee HE, Kaiser MF, Wechalekar A, Benjamin R, Apperley JF, Auner HW, Franzoso G. Preclinical toxicology and safety pharmacology of the first-in-class GADD45β/MKK7 inhibitor and clinical candidate, DTP3. Toxicol Rep. 2019 Apr 19;6:369-379. doi: 10.1016/j.toxrep.2019.04.006. PMID: 31080744; PMCID: PMC6502747. |
