For research use only. Not for therapeutic Use.
DU125530 is a selective 5-HT1A receptor antagonist (Ki value of 0.7 nM). DU-125530 showed equal (low nM) potency to displace agonist and antagonist binding to pre- and post-synaptic 5-HT1A receptors in rat and human brain.
KEYWORDS: DU125530 | supplier | 5-HT1A antagonist | DU 125530 | DU-125530 | CAS [161611-99-0] | Serotonin | 5-HT1A | Antagonist | Receptors
| Catalog Number | I006556 |
| CAS Number | 161611-99-0 |
| Molecular Formula | C23H26ClN3O5S |
| Purity | ≥95% |
| IUPAC Name | 2-[4-[4-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)piperazin-1-yl]butyl]-1,1-dioxo-1,2-benzothiazol-3-one |
| InChI | InChI=1S/C23H26ClN3O5S/c24-17-15-19(22-20(16-17)31-13-14-32-22)26-11-9-25(10-12-26)7-3-4-8-27-23(28)18-5-1-2-6-21(18)33(27,29)30/h1-2,5-6,15-16H,3-4,7-14H2 |
| SMILES | C1CN(CCN1CCCCN2C(=O)C3=CC=CC=C3S2(=O)=O)C4=C5C(=CC(=C4)Cl)OCCO5 |
| Reference | J Mos et al. The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons. Eur J Pharmacol. 1997 May 1;325(2-3):145-53.
MC Scorza et al. Preclinical and clinical characterization of the selective 5-HT(1A) receptor antagonist DU-125530 for antidepressant treatment. Br J Pharmacol. 2012 Nov;167(5):1021-34. |
