DUB-IN-1

• CAT Number: I005502
• CAS Number: 924296-18-4
• Molecular Formula: C20H11N5O
• Molecular Weight: 337.33
• Purity: ≥95%
• Synonyms: (9E)-9-phenylmethoxyiminoindeno[1,2-b]pyrazine-2,3-dicarbonitrile
• InChI: InChI=1S/C20H11N5O/c21-10-16-17(11-22)24-20-18(23-16)14-8-4-5-9-15(14)19(20)25-26-12-13-6-2-1-3-7-13/h1-9H,12H2/b25-19+
• InChIKey: GKOWDIBLCDZJHF-NCELDCMTSA-N
• SMILES: C1=CC=C(C=C1)CON=C2C3=CC=CC=C3C4=NC(=C(N=C42)C#N)C#N

DUB-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.85 μM for USP8[1].
DUBs-IN-1 (22 d) is an active inhibitor of ubiquitin-specific proteases, with an IC50 of 0.85 μM for USP8. DUBs-IN-1 is inactive toward USP7 (IC50, >100 μM). DUBs-IN-1 and its analogs reduce the viability of HCT116 colon and PC-3 prostate cancer cell lines with IC50s ranging from 0.5 μM to 1.5 μM[1].

Reference

[1]. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.
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