DUB-IN-2

• CAT Number: I005503
• CAS Number: 924296-19-5
• Molecular Formula: C15H9N5O
• Molecular Weight: 275.26
• Purity: ≥95%
• Synonyms: (9E)-9-ethoxyiminoindeno[1,2-b]pyrazine-2,3-dicarbonitrile
• InChI: InChI=1S/C15H9N5O/c1-2-21-20-14-10-6-4-3-5-9(10)13-15(14)19-12(8-17)11(7-16)18-13/h3-6H,2H2,1H3/b20-14+
• InChIKey: VKVAJBRQGBRHIK-XSFVSMFZSA-N
• SMILES: CCON=C1C2=CC=CC=C2C3=NC(=C(N=C31)C#N)C#N

DUB-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8[1].
DUBs-IN-2 (compound 22 e) is a potent USP8 inhibitor with an IC50 of 0.28 μM, and has no effect on USP7, with an IC50 of >100 μM. DUBs-IN-2 inhibits the viability of HCT116 colon cell line and PC-3 prostate cancer cell line with IC50 values of 0.5-1.5?μM[1].

Reference

[1]. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.
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