DUB-IN-3

• CAT Number: I005501
• CAS Number: 924296-17-3
• Molecular Formula: C16H9N5O
• Molecular Weight: 287.28
• Purity: ≥95%
• Synonyms: (9E)-9-prop-2-enoxyiminoindeno[1,2-b]pyrazine-2,3-dicarbonitrile
• InChI: InChI=1S/C16H9N5O/c1-2-7-22-21-15-11-6-4-3-5-10(11)14-16(15)20-13(9-18)12(8-17)19-14/h2-6H,1,7H2/b21-15+
• InChIKey: XLOXSIKLUAMDGU-RCCKNPSSSA-N
• SMILES: C=CCON=C1C2=CC=CC=C2C3=NC(=C(N=C31)C#N)C#N

DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c with an IC50 of 0.56 μM for USP8[1].

Reference

[1]. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.
 [Content Brief]