Duocarmycin MA

• CAT Number: I018765
• CAS Number: 1613286-57-9
• Molecular Formula: C₃₄H₃₁ClN₄O₅
• Molecular Weight: 611.09
• Purity: ≥95%
• Target: Cell Cycle/DNA Damage
• IUPAC Name: tert-butyl N-[4-[[2-[(1S)-1-(chloromethyl)-5-hydroxy-1,2-dihydrobenzo[e]indole-3-carbonyl]-1H-indol-6-yl]carbamoyl]phenyl]carbamate
• InChI: InChI=1S/C34H31ClN4O5/c1-34(2,3)44-33(43)37-22-11-8-19(9-12-22)31(41)36-23-13-10-20-14-27(38-26(20)15-23)32(42)39-18-21(17-35)30-25-7-5-4-6-24(25)29(40)16-28(30)39/h4-16,21,38,40H,17-18H2,1-3H3,(H,36,41)(H,37,43)/t21-/m1/s1
• InChIKey: MZXQBIDDBQCHFP-OAQYLSRUSA-N
• SMILES: CC(C)(C)OC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC3=C(C=C2)C=C(N3)C(=O)N4C[C@H](C5=C4C=C(C6=CC=CC=C65)O)CCl

Duocarmycin MA(CAT: I018765) is a highly potent DNA-alkylating agent derived from natural products, widely utilized in cancer research and drug development. It exerts its cytotoxic effects by binding to the minor groove of DNA and inducing sequence-specific alkylation, leading to irreversible DNA damage and apoptosis in rapidly proliferating tumor cells. Duocarmycin MA is particularly valuable in the development of antibody-drug conjugates (ADCs) as its potency ensures targeted therapeutic efficacy at low concentrations. With its high specificity and robust activity, it is an essential tool for studying DNA-targeting chemotherapeutic agents and advancing innovative cancer therapies.