For research use only. Not for therapeutic Use.
Duocarmycin TM (Cat.No:I019771) is a potent antitumor antibiotic with cytotoxic properties. It belongs to the duocarmycin family and exhibits DNA alkylating activity, leading to cell cycle arrest and apoptosis in cancer cells. Duocarmycin TM shows promise as a potential therapeutic agent in the treatment of various cancers.
| Catalog Number | I019771 |
| CAS Number | 157922-77-5 |
| Molecular Formula | C₂₅H₂₃ClN₂O₅ |
| Purity | ≥95% |
| IUPAC Name | [(1S)-1-(chloromethyl)-5-hydroxy-1,2-dihydrobenzo[e]indol-3-yl]-(5,6,7-trimethoxy-1H-indol-2-yl)methanone |
| InChI | InChI=1S/C25H23ClN2O5/c1-31-20-9-13-8-17(27-22(13)24(33-3)23(20)32-2)25(30)28-12-14(11-26)21-16-7-5-4-6-15(16)19(29)10-18(21)28/h4-10,14,27,29H,11-12H2,1-3H3/t14-/m1/s1 |
| InChIKey | NRHDGIYFJJUFKN-CQSZACIVSA-N |
| SMILES | COC1=C(C(=C2C(=C1)C=C(N2)C(=O)N3C[C@H](C4=C3C=C(C5=CC=CC=C54)O)CCl)OC)OC |
| Reference | [1]. Dale L. Boger, et al. Critical Role of the Linking Amide in CC-1065 and the Duocarmycins: Implications on the Source of DNA Alkylation Catalysis. J. Am. Chem. Soc. 1998, 120, 11554-11557. |
