Durlobactam

• CAT Number: I026606
• CAS Number: 1467829-71-5
• Molecular Formula: C8H11N3O6S
• Molecular Weight: 277.25
• Purity: 98%
• Synonyms: ETX2514; ETX-2514; ETX 2514; Durlobactam; Durlobactam.
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (1R,2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl hydrogen sulfate
• InChI: InChI=1S/C8H11N3O6S/c1-4-2-5-3-10(6(4)7(9)12)8(13)11(5)17-18(14,15)16/h2,5-6H,3H2,1H3,(H2,9,12)(H,14,15,16)/t5-,6+/m1/s1
• InChIKey: BISPBXFUKNXOQY-RITPCOANSA-N
• SMILES: O=S(O)(ON1[C@]2([H])C=C(C)[C@@H](C(N)=O)[N@@](C2)C1=O)=O

Durlobactam, also known as ETX2514, is a beta-lactamase inhibitor drug candidate. Sulbactam-durlobactam (formerly sulbactam-ETX2514) (SUL-DUR) is a β-lactam/β-lactamase inhibitor combination antibiotic designed to treat serious infections caused by ABC, including multidrug-resistant (MDR) strains. SUL-DUR had a MIC50/MIC90 of 1/2 μg/ml compared to a MIC50/MIC90 of 8/64 μg/ml for sulbactam alone.