DY131

• CAT Number: I005650
• CAS Number: 95167-41-2
• Molecular Formula: C18H21N3O2
• Molecular Weight: 311.41
• Purity: ≥95%
• Synonyms: DY-131; GSK 9089
• Target: Stem Cell/Wnt
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: N-[(E)-[4-(diethylamino)phenyl]methylideneamino]-4-hydroxybenzamide
• InChI: InChI=1S/C18H21N3O2/c1-3-21(4-2)16-9-5-14(6-10-16)13-19-20-18(23)15-7-11-17(22)12-8-15/h5-13,22H,3-4H2,1-2H3,(H,20,23)/b19-13+
• InChIKey: WLKOCYWYAWBGKY-CPNJWEJPSA-N
• SMILES: CCN(CC)C1=CC=C(C=C1)/C=N/NC(=O)C2=CC=C(C=C2)O

DY131 (CAT: I005650) is a selective agonist of estrogen-related receptors ERRβ and ERRγ, with minimal activity at ERRα, ERα, and ERβ up to 30 μM. It enhances ERRγ-induced growth inhibition in LNCaP-ERRγ and DU145-ERRγ prostate cancer cells in a dose-dependent manner and inhibits the growth of ERα-positive endometrial cancer cells while promoting growth in ERα-negative cells. DY131 also inhibits Smoothened (Smo) signaling by targeting a common binding site shared by Smo modulators. This compound is a valuable tool for research on ERR-specific mechanisms, hormone-responsive cancers, and Hedgehog pathway modulation, offering insights into receptor-selective therapeutic strategies.