Dyclonine HCl

For research use only. Not for therapeutic Use.

  • CAT Number: A000385
  • CAS Number: 536-43-6
  • Molecular Formula: C18H27NO2.HCl
  • Molecular Weight: 325.87
  • Purity: ≥95%
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Dyclonine HCl(Cat No.:A000385)is a local anesthetic commonly used for topical pain relief in throat lozenges, oral sprays, and dental procedures. It works by blocking nerve conduction, providing temporary numbing of mucous membranes to reduce pain and discomfort. Known for its rapid onset and mild, long-lasting effects, dyclonine HCl is effective in alleviating sore throat, oral irritation, and minor dental pain. It is generally well-tolerated and widely used in over-the-counter formulations, making it a popular choice for short-term, localized anesthesia in both medical and home settings.


Catalog Number A000385
CAS Number 536-43-6
Synonyms

NA

Molecular Formula C18H27NO2.HCl
Purity ≥95%
Target Metabolic Enzyme/Protease
Storage 3 years -20C powder
IUPAC Name 1-(4-butoxyphenyl)-3-piperidin-1-ylpropan-1-one;hydrochloride
InChI InChI=1S/C18H27NO2.ClH/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19;/h7-10H,2-6,11-15H2,1H3;1H
InChIKey KNZADIMHVBBPOA-UHFFFAOYSA-N
SMILES CCCCOC1=CC=C(C=C1)C(=O)CCN2CCCCC2.Cl
Reference

</br>1: Schmidt AC. Solid-state characterization of falicaine hydrochloride and</br> isomorphic dyclonine hydrochloride. Part IV. Crystal polymorphism of local</br> anaesthetic drugs. Eur J Pharm Sci. 2005 Jul-Aug;25(4-5):407-16. PubMed PMID:</br> 15896948.</br>2: Bacon GS, Lyons TR, Wood SH. Dyclonine hydrochloride for airway anesthesia:</br> awake endotracheal intubation in a patient with suspected local anesthetic</br> allergy. Anesthesiology. 1997 May;86(5):1206-7. PubMed PMID: 9158369.</br>3: Liang CY, Yang Y, Khadim MA, Banker GS, Kumar V. Isolation and</br> characterization of two major degradation products of dyclonine hydrochloride. J </br> Pharm Sci. 1995 Sep;84(9):1141-3. PubMed PMID: 8537897.</br>4: Bhagat HR, Bhargava HN, Williams DA. High-performance liquid chromatographic</br> determination of dyclonine hydrochloride in the presence of its degradation</br> products. J Pharm Biomed Anal. 1989;7(4):441-6. PubMed PMID: 2490751.</br>5: Purcell SM, Dixon SL. Allergic contact dermatitis to dyclonine hydrochloride</br> simulating extensive herpes simplex labialis. J Am Acad Dermatol. 1985 Feb;12(2</br> Pt 1):231-4. PubMed PMID: 3973123.</br>6: WHEELER DE. Bronchography using dyclonine hydrochloride anesthesia (4</br> N-butoxy-beta-piperidino-propiophenone-hydrochloride). Dis Chest. 1960</br> Feb;37:193-5. PubMed PMID: 13844280.</br>7: FLORESTANO HJ, BAHLER ME. Antimicrobial properties of dyclonine hydrochloride,</br> a new topical anesthetic. J Am Pharm Assoc Am Pharm Assoc. 1956 May;45(5):320-5. </br> PubMed PMID: 13319121.</br>8: Gargiulo AV, Burns GM, Huck CP. Dyclonine hydrochloride–a topical agent for</br> managing pain. Ill Dent J. 1992 Jul-Aug;61(4):303-4. PubMed PMID: 1286862.</br>9: Nelson LA. Nonprescription drug screening. Dyclonine hydrochloride. Am Pharm. </br> 1987 Sep;NS27(9):27-9. PubMed PMID: 3425542.</br>10: Palermo PJ. High pressure liquid chromatographic determination of dyclonine</br> hydrochloride and its degradation products in cough lozenges and liquids. J Pharm</br> Biomed Anal. 1987;5(4):423-30. PubMed PMID: 16867513.</br>11: Maibach HI. Dyclonine hydrochloride, local anaesthetic allergic contact</br> dermatitis. Contact Dermatitis. 1986 Feb;14(2):114. PubMed PMID: 3709147.</br>12: PING RS, WHITE JG, SPEAR LB. Dyclonine hydrochloride as a topical anesthetic </br> in dentistry; a preliminary report. Oral Surg Oral Med Oral Pathol. 1957</br> Jun;10(6):623-6. PubMed PMID: 13441277.</br>13: DYCLONINE hydrochloride. J Am Med Assoc. 1956 Sep 8;162(2):116-7. PubMed</br> PMID: 13357302.</br>14: MORGINSON WJ, RICH CO, ESKELSON YD, KIRKMAN LW, UTTERBACK M, BURTON AM,</br> COLETTI JM. Dyclonine hydrochloride: a new topical antipruritic agent. Postgrad</br> Med. 1956 Jun;19(6):605-7. PubMed PMID: 13335606.</br>15: FISHER HE. Dyclonine hydrochloride; evaluation of a new topical anesthetic in</br> minor urologic technics. Mo Med. 1955 Dec;52(12):943-4. PubMed PMID: 13272680.</br>16: SHELMIRE B, GASTINEAU FM, SHIELDS TL. Evaluation of a new topical anesthetic,</br> dyclonine hydrochloride. AMA Arch Derm. 1955 Jun;71(6):728-30. PubMed PMID:</br> 14375392.</br></br>

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