Dynole 2−24

• CAT Number: I045185
• CAS Number: 1416313-72-8
• Molecular Formula: C24H41N3
• Molecular Weight: 371.60
• Purity: ≥95%
• Synonyms: N-[[1-[3-(dimethylamino)propyl]indol-3-yl]methyl]decan-1-amine
• InChI: InChI=1S/C24H41N3/c1-4-5-6-7-8-9-10-13-17-25-20-22-21-27(19-14-18-26(2)3)24-16-12-11-15-23(22)24/h11-12,15-16,21,25H,4-10,13-14,17-20H2,1-3H3
• InChIKey: ZXKCYZJGHXORKJ-UHFFFAOYSA-N
• SMILES: CCCCCCCCCCNCC1=CN(C2=CC=CC=C21)CCCN(C)C

Dynole 2−24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2−24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM). Dynole 2−24 also shows 4.4-fold selectivity for dynamin I. Dynole 2−24 is active in-cell inhibitor of clathrin-mediated endocytosis[1]. CME: Clathrin mediated endocytosis

Reference

[1]. Gordon CP, Venn-Brown B, Robertson MJ, et al. Development of second-generation indole-based dynamin GTPase inhibitors. J Med Chem. 2013;56(1):46-59.
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