For research use only. Not for therapeutic Use.
Dynole 34-2 is a dynamin GTPase inhibitor (IC50s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage[1]. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME)[2].
| Catalog Number | I010918 |
| CAS Number | 1128165-88-7 |
| Synonyms | (E)-2-cyano-3-[1-[3-(dimethylamino)propyl]indol-3-yl]-N-octylprop-2-enamide |
| Molecular Formula | C25H36N4O |
| Purity | ≥95% |
| InChI | InChI=1S/C25H36N4O/c1-4-5-6-7-8-11-15-27-25(30)21(19-26)18-22-20-29(17-12-16-28(2)3)24-14-10-9-13-23(22)24/h9-10,13-14,18,20H,4-8,11-12,15-17H2,1-3H3,(H,27,30)/b21-18+ |
| InChIKey | MYIMRONQBLZJFI-DYTRJAOYSA-N |
| SMILES | CCCCCCCCNC(=O)C(=CC1=CN(C2=CC=CC=C21)CCCN(C)C)C#N |
| Reference | [1]. Chircop M, et al. Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells. Mol Cancer Ther. 2011 Sep;10(9):1553-62. [2]. Hill TA, et al. Inhibition of dynamin mediated endocytosis by the dynoles–synthesis and functional activity of a family of indoles. J Med Chem. 2009 Jun 25;52(12):3762-73. |
