Dyrk1A-IN-4

• CAT Number: I043666
• CAS Number: 2091883-59-7
• Molecular Formula: C14H13F3N6
• Molecular Weight: 322.29
• Purity: ≥95%
• Synonyms: 4-[2-methyl-3-(2,2,2-trifluoroethyl)imidazo[4,5-b]pyridin-5-yl]pyridine-2,6-diamine
• InChI: InChI=1S/C14H13F3N6/c1-7-20-10-3-2-9(8-4-11(18)22-12(19)5-8)21-13(10)23(7)6-14(15,16)17/h2-5H,6H2,1H3,(H4,18,19,22)
• InChIKey: QHTJZFWEQYRYQE-UHFFFAOYSA-N
• SMILES: CC1=NC2=C(N1CC(F)(F)F)N=C(C=C2)C3=CC(=NC(=C3)N)N

Dyrk1A-IN-4（Cat No.:I043666）is a potent inhibitor of the DYRK1A (Dual-specificity tyrosine-phosphorylation-regulated kinase 1A) enzyme, which plays a critical role in various cellular processes, including cell cycle regulation and neurodevelopment. This compound is being investigated for its therapeutic potential in neurodegenerative diseases like Alzheimer’s disease and Down syndrome, as DYRK1A dysregulation has been linked to cognitive impairments. By selectively inhibiting DYRK1A, Dyrk1A-IN-4 may improve cognitive function and neuronal survival. Ongoing research aims to further explore its efficacy and safety as a targeted treatment for these conditions.