For research use only. Not for therapeutic Use.
E-6005(CAT: I006570) is a compound that acts as a phosphodiesterase 4 (PDE-4) inhibitor. It holds potential for the treatment of atopic dermatitis, a chronic inflammatory skin condition. By inhibiting PDE-4, E-6005 helps increase the levels of intracellular cyclic adenosine monophosphate (cAMP), which in turn modulates inflammatory responses. Through its anti-inflammatory effects, E-6005 may alleviate the symptoms associated with atopic dermatitis, such as itching, redness, and skin inflammation.
| Catalog Number | I006570 |
| CAS Number | 947620-48-6 |
| Synonyms | E-6005; E6005; E6005;methyl 4-((3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenyl)carbamoyl)benzoate |
| Molecular Formula | C26H24N4O5 |
| Purity | ≥95% |
| Target | Phosphodiesterase (PDE) |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| InChI | InChI=1S/C26H24N4O5/c1-27-26-29-20-14-22(34-3)21(33-2)13-19(20)23(30-26)17-6-5-7-18(12-17)28-24(31)15-8-10-16(11-9-15)25(32)35-4/h5-14H,1-4H3,(H,28,31)(H,27,29,30) |
| InChIKey | BBTFKAOFCSOZMB-UHFFFAOYSA-N |
| SMILES | O=C(OC)C1=CC=C(C(NC2=CC=CC(C3=C4C=C(OC)C(OC)=CC4=NC(NC)=N3)=C2)=O)C=C1 |
| Reference | </br>1:Nemoto O, Hayashi N, Kitahara Y, Furue M, Hojo S, Nomoto M, Shima S; Japanese E6005 Study Investigators.. Effect of topical phosphodiesterase 4 inhibitor E6005 on Japanese children with atopic dermatitis: Results from a randomized, vehicle-controlled exploratory trial. J Dermatol. 2016 Aug;43(8):881-7. doi: 10.1111/1346-8138.13231. PubMed PMID: 26703371. |
