(E)-Doxepin Hydrochloride

• CAT Number: R042852
• CAS Number: 4698-39-9
• Molecular Formula: C19H22ClNO
• Molecular Weight: 315.841
• Purity: ≥95%
• Synonyms: (3E)-3-Dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine Hydrochloride; (E)-3-Dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine Hydrochloride; (E)-N,N-dimethyl-Dibenz[b,e]oxepin-Δ11(6H),γ-propylamine Hydrochloride; Dibenz[b,e]oxe
• Storage: -20°C
• IUPAC Name: (3E)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine;hydrochloride
• InChI: InChI=1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11+
• InChIKey: MHNSPTUQQIYJOT-SJDTYFKWSA-N
• SMILES: CN(C)CCC=C1C2=CC=CC=C2COC3=CC=CC=C31.Cl

(E)-Doxepin Hydrochloride is a tricyclic antidepressant (TCA) primarily used to treat depression, anxiety disorders, and insomnia. It works by inhibiting the reuptake of neurotransmitters such as serotonin and norepinephrine, thus improving mood and reducing anxiety. The (E)-isomer refers to its specific geometric configuration, contributing to its pharmacological activity. Additionally, doxepin has antihistamine properties, making it effective in treating chronic hives and other allergic conditions. It remains a valuable treatment option in both mental health and dermatological care.