For research use only. Not for therapeutic Use.
(E/Z)-E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity[1][2].
| Catalog Number | I045511 |
| CAS Number | 2285446-67-3 |
| Synonyms | (1E)-1-nonylidene-3-(trifluoromethyl)indene-5,6-diol |
| Molecular Formula | C19H23F3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H23F3O2/c1-2-3-4-5-6-7-8-9-13-10-16(19(20,21)22)15-12-18(24)17(23)11-14(13)15/h9-12,23-24H,2-8H2,1H3/b13-9+ |
| InChIKey | OWYMWLCFHDHVAH-UKTHLTGXSA-N |
| SMILES | CCCCCCCCC=C1C=C(C2=CC(=C(C=C21)O)O)C(F)(F)F |
| Reference | [1]. Nathan G. Dolloff, et al. Indene derivatives and uses thereof. US20190062298A1. [2]. Robinson RM, et al. Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma. Leukemia. 2019 Apr;33(4):1011-1022. |
