(E/Z)-SIB-1893

• CAT Number: I010379
• CAS Number: 6266-99-5
• Molecular Formula: C14H13N
• Molecular Weight: 195.26
• Purity: ≥95%
• Synonyms: 2-methyl-6-[(E)-2-phenylethenyl]pyridine
• InChI: InChI=1S/C14H13N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-11H,1H3/b11-10+
• InChIKey: SISOFUCTXZKSOQ-ZHACJKMWSA-N
• SMILES: CC1=NC(=CC=C1)C=CC2=CC=CC=C2

(E/Z)-SIB-1893 is a racemic compound of (E)-SIB-1893 and (Z)-SIB-1893 isomers. (E)-SIB-1893 is a selective non-competitive metabotropic glutamate subtype 5 receptor (mGluR5) antagonist[1].
(E)-SIB-1893 produces hypothermia in freely moving rats in a dose-dependent manner[1].

Reference

[1]. Łuszczki JJ, et al. Non-competitive metabotropic glutamate subtype 5 receptor antagonist (SIB-1893) decreases body temperature in rats. Pharmacol Rep. 2005;57(6):795-801.
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