For research use only. Not for therapeutic Use.
E1210（Cat No.:I017467）is a novel antifungal agent under research for its potent and broad-spectrum activity against fungal pathogens. It works by inhibiting glycosylphosphatidylinositol (GPI) anchor biosynthesis, a crucial pathway for fungal cell wall integrity and growth. Effective against Candida, Aspergillus, and other resistant strains, E1210 shows promise in treating invasive fungal infections with minimal toxicity to human cells. Its unique mechanism of action addresses limitations of existing antifungals, reducing cross-resistance concerns. Current studies focus on its pharmacokinetics, safety profile, and potential for combination therapies to improve antifungal treatment outcomes.
| Catalog Number | I017467 |
| CAS Number | 936339-60-5 |
| Molecular Formula | C₂₁H₁₈N₄O₂ |
| Purity | ≥95% |
| Target | Fungal |
| Storage | Store at -20°C |
| IUPAC Name | 3-[3-[[4-(pyridin-2-yloxymethyl)phenyl]methyl]-1,2-oxazol-5-yl]pyridin-2-amine |
| InChI | InChI=1S/C21H18N4O2/c22-21-18(4-3-11-24-21)19-13-17(25-27-19)12-15-6-8-16(9-7-15)14-26-20-5-1-2-10-23-20/h1-11,13H,12,14H2,(H2,22,24) |
| InChIKey | WSEKTEUGRLFBSE-UHFFFAOYSA-N |
| SMILES | C1=CC=NC(=C1)OCC2=CC=C(C=C2)CC3=NOC(=C3)C4=C(N=CC=C4)N |
| Reference | [1]. Watanabe NA, et al. E1210, a new broad-spectrum antifungal, suppresses Candida albicans hyphal growth through inhibition of glycosylphosphatidylinositol biosynthesis. Antimicrob Agents Chemother. 2012 Feb;56(2):960-71.<br>[2]. Hata K, et al. Efficacy of oral E1210, a new broad-spectrum antifungal with a novel mechanism of action, in murine models of candidiasis, aspergillosis, and fusariosis. Antimicrob Agents Chemother. 2011 Oct;55(10):4543-51. |
